BONE LOSS WITH AGE--EPIDEMIOLOGY, FAMILIAL AND CROSS-CULTURAL CONSIDERATIONS

在生命的第四个十年里，人类的骨骼开始失去骨骼。 也就是说，骨量相对于骨量减少。更年期和 与之相关的雌激素缺乏会加剧女性的骨质流失。它 也被怀疑骨丢失是家族性的，主要是因为 骨质疏松症在亲属中的患病率增加，尽管没有 令人满意的科学数据支持家族或基因 控制骨丢失。在长骨中，皮质骨是从 骨内膜表面。由于皮质骨壳变薄， 骨骼失去其机械完整性，更容易骨折。这个 脊柱的骨小梁质量也随着年龄的增长而减少。 椎体压缩骨折和股骨颈骨折 骨质流失的最严重后果。 该项目涉及流行病学、遗传学、横断面、 骨丢失的纵向和生物力学方面(1) 巴尔的摩老龄化纵向研究(BLSA)的参与者，(2) 克罗地亚亚得里亚海群岛和亚得里亚海岛屿的基因分离 密克罗尼西亚、日本、中美洲、阿尔巴尼亚和其他地区的关岛 世界(跨文化)，(3)在老鼠身上。

During the fourth decade of life, the human skeleton begins to lose bone. That is, bone mass decreases in relation to bone volume. Menopause and the associated estrogen deficiency will enhance bone loss in females. It has also been suspected that bone loss is familial, mainly because of the increased prevalence of osteoporosis in relatives, although there are no satisfactory scientific data to support either a familial or a genetic control of bone loss. In long bones, cortical bone is resorbed from the endosteal surface. Because of the thinning of the cortical bone shell, bones lose their mechanical integrity and fracture more readily. The trabecular bone mass of the vertebral column also decreases with age. Vertebral compression fractures and fractures of the femoral neck are the most serious consequences of bone loss. This project deals with the epidemiological, genetic, cross-sectional, longitudinal, and biomechanical aspects of bone loss (1) among the participants of the Baltimore Longitudinal Study of Aging (BLSA), (2) in genetic isolates of the Adriatic Sea Islands of Croatia and the island of Guam in Micronesia, Japan, Central America, Albania and other parts of the world (cross-cultural), (3) in rats.