EFFECTS OF CHRONIC BROMIDE INTOXICATION ON LOCAL CEREBRAL GLUCOSE UTILIZATION

慢性溴中毒导致精神分裂症样综合征 天哪。为了确定可能涉及大脑中的哪些结构，我们正在 脑部局部葡萄糖利用的研究 [14C]溴化物慢性染毒大鼠的脱氧葡萄糖方法 在饮用水中最多10天，在水中和 渗透泵使用时间长达49天。在大鼠中只给予溴化物 饮用水血清溴水平提高至约200毫克溴化钠/L 2天400 mg/L，6天400 mg/L，10天425 mg/L。在对照组大鼠中 只给水，血清溴水平在0到12.3 mg/L之间。 饮用水和渗透压泵血清中同时给予溴化物的大鼠 14天前平均水平为420毫克/L，21天前为540毫克/L L剂量为35天，L剂量为525 mg/次，剂量49天。对照组大鼠血清中的溴化物 水平在0到59毫克/L之间。平均葡萄糖利用率 到目前为止，已经在34只大鼠身上测定了整个大脑中的。在大鼠身上 用溴化物处理21d后，葡萄糖利用率 与对照组相比下降12.5%(p&lt；0.05，分组t检验)。 分析仍在继续，将包括当地的 大脑中葡萄糖的利用。

Chronic bromide intoxication produces a schizophrenia-like syndrome in man. To determine which structures in brain might be involved, we are studying local cerebral glucose utilization (LCGU) with the [14C]deoxyglucose method in rats being administered bromides chronically in the drinking water for up to 10 days and in both the water and by osmotic pump for up to 49 days. In rats given bromides only in the drinking water serum bromide levels were raised to about 200 mg NaBr/l in 2 days, 400 mg/l in 6 days, and 425 mg/l in 10 days. In control rats given only water serum bromide levels were between 0 and 12.3 mg/l. In rats given bromides in both drinking water and by osmotic pump serum bromide levels averaged 420 mg/l by 14 days, 540 mg/l by 21 days, 540 mg/l by 35 days, and 525 mg/l by 49 days. In control rats serum bromide levels ranged between 0 and 59 mg/l. Average rates of glucose utilization in the brain as a whole have thus far been determined in 34 rats. In rats treated for 21 days with bromide rates of glucose utilization were decreased by 12.5% compared with controls (p<0.05), grouped t-test). Analyses are still being continued and will include local rates of glucose utilization in the brain.