DEVELOPMENT OF AN EMBRYO CRYOPRESERVATION PROGRAM IN LABORATORY ANIMALS

美国国立卫生研究院动物遗传资源（NIHAGR）保存了几种动物物种， 以及一个物种中许多无价的基因型， 在生物医学研究中。 为了保护这种种质， 作为一种经济手段建立，以无限期地保存这些股票 以及啮齿动物和兔子的品系。 胚胎冷冻保存 基因型管理的其他好处，如防止损失 疾病、繁殖失败、自然灾害或 基因污染 冷冻库最大限度地减少了由于遗传 通过提供一个资源来定期重新派生定义的 用于基础育种群体的重新标准化的基因型。 作为 公认的实验室动物物种库，NIHAGR定期 在整个生物医学研究过程中，应要求提供育种细胞核 社区 与其运输活体动物， 代表了一种更简单、更人性化和更容易的运输方法 全世界的遗传物质。 胚胎处理的另一个重要影响， 冷冻保存和转移程序是消除垂直 一些鼠疾病的传播。

The NIH Animal Genetic Resource (NIHAGR) maintains several animal species and many invaluable genotypes within a species, which are used as models in biomedical research. To protect this germ plasm, an embryo bank was established as an economical means to indefinitely preserve these stocks and strains of rodents and rabbits. Cryopreservation of embryos has other benefits for genotype management such as safeguarding against loss of germ plasm from disease, reproductive failure, natural catastrophe or genetic contamination. The cryobank minimizes changes due to genetic drift by providing a resource from which to periodically rederive defined genotypes for restandardization of foundation breeding colonies. As a recognized repository for laboratory animal species, the NIHAGR routinely provides breeding nuclei upon request throughout the biomedical research community. Rather than shipping live animals, cryopreserved embryos represent a simpler, more humane and easier method to transport requested germ plasm worldwide. Another important impact of embryo handling, cryopreservation, and transfer procedures is to eliminate the vertical transmission of some murine diseases.