POLYMER GEL FOR CLINICAL 3D RADIATION DOSIMETRY BY MRI

本项目旨在开发一种新型的、组织等效的凝胶剂量计， 电离辐射，它能够产生高分辨率， 使用磁共振成像的三维剂量分布的精确数据 磁共振成像（MRI）。剂量反应机制依赖于 增强凝胶中水的质子NMR弛豫 辐射吸收，其中分散在凝胶中的丙烯酸共聚单体是 聚合的10戈伊量级的剂量可以用空间剂量计测量。 分辨率小于1 mm。此外，本发明还提供了一种方法， 透明凝胶的光学浊度随吸收剂量的增加而增加 因为共聚物从水中沉淀， 分布也可以光学可视化。凝胶会发现 在放射治疗实践中广泛使用， 同质和拟人化的幻影，确认计算机化的 治疗计划和质量保证程序。阶段的目标 我要设计和评估一个既方便又便宜的方案 原型聚合物-凝胶剂量计的制备，并证明其 稳定性和再现性以及剂量的空间均匀性- 反应这些研究将为发展 更高效的聚合物凝胶。

This project aims to develop a novel, tissue-equivalent gel-dosimeter of ionizing radiation, which is capable of producing highly-resolved and accurate data on three dimensional dose distributions using magnetic resonance imaging (MRI). The dose-response mechanism relies on the enhancement of the proton NMR relaxation of water in the gel at the site of radiation absorption, where acrylic comonomers dispersed in the gel are polymerized. Doses of the order of 10 Gy can be measured with a spatial resolution less than lmm using clinical MR imaging equipment. In addition, the optical turbidity of the transparent gel increases with absorbed dose because the copolymer precipitates from water, and thus the dose distribution can also be optically visualized. The gel will find widespread use in radiation therapy practice, for 3D measurements in homogeneous and anthropomorphic phantoms, confirmation of computerized treatment planning and in quality assurance procedures. The goals of Phase I are to devise and evaluate a protocol for convenient and inexpensive preparation of a prototype polymer-gel dosimeter, and to demonstrate its stability and reproducibility as well as spatial uniformity of the dose- response. These studies will prepare the ground for the development of more efficient polymer-gels in Phase II.