BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

与年龄相关的骨量变化在男性和女性中都被证实 女人。与年龄相关的骨丢失的因果作用被归因于 骨矿调节荷尔蒙维生素D状态的变化 和/或肾功能。据推测，维他命受损 D状态和/或循环水平的活跃，荷尔蒙形式的 维生素是衰老的伴生物，是骨骼的一部分。 在老年人身上看到的失落。巴尔的摩纵向研究中的研究 衰老已经证明，不同年龄段的人没有区别 正常男性或女性的25-OHD或1，25(OH)2D水平。无论是男人还是 女性的甲状旁腺激素水平与年龄相关，而不是 与内生肌酐清除量独立相关。为了确定 这些参数与骨量之间的关系 转化(骨钙素和尿钙)为骨量、骨矿物质 测量三个部位(桡骨、脊柱和股骨)的密度(BMD)。 BLSA的正常男女。血清25-OHD、1，25(OH)2D和PTH 与年轻男性(48岁)或老年人(60岁)任何部位的骨密度无关 女人。然而，在老年男性中，较低的年龄调整后的半径骨密度是 与较高的甲状旁腺素和1，25(OH)2D和较低的25 OHD显著相关 价值观。股骨骨密度横断面下降的年轻男性 可与老年人媲美，具有重要的高价值联想 用于年龄调整后骨密度低的骨转换标志物。这些结果 强调了骨丢失的异质性及其相关因素。 这种异质性部分取决于年龄、性别和特定的 牵涉到骨骼部位。

Age-related changes in bone mass have been demonstrated in both men and women. A causal role in age-related bone loss has been attributed to alterations in vitamin D status, the bone mineral regulating hormones and/or renal function. it has been hypothesized that compromised vitamin D status and/or circulating levels of the active, hormonal form of the vitamin are a concomitant of aging and are responsible for part of the bone loss seen in the elderly. Studies in the Baltimore Longitudinal Study of Aging have demonstrated that there are no differences across the age span in 25-OHD or 1,25 (OH)2 D levels in normal men or women. Both men and women had an age associated increase in PTH levels that was not independently correlated with creatinine clearance. In order to determine the relationship between these parameters as well as measures of bone turnover (osteocalcin and urinary calcium) to bone mass, bone mineral density (BMD) at three sites (radius, spine and femur) was measured in normal men and women of the BLSA. Serum 25-OHD, 1,25(OH)2 D, and PTH were not related to BMD at any site in young (<48 years) men or old (>60 yrs) women. However, in old men, lower age-adjusted radius BMD was significantly associated with higher PTH and 1,25(OH)2 D and lower 25 OHD values. Young men, who had a cross-sectional decline in femoral BMD comparable to that of old men, had significant associations of high values for the markers of bone turnover with low age-adjusted BMD. These results emphasized the heterogeneity of bone loss and factors associated with it. This heterogeneity is partially dependent on age, gender, and the specific bone site involved.