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VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS

VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
弥漫性狼疮性肾炎的各种细胞毒性药物方案
批准号：
3810926
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3810926
关键词：
biopsy combination chemotherapy connective tissue disorder chemotherapy corticosteroids cyclophosphamide cytotoxicity dosage drug administration rate /duration drug administration routes drug adverse effect human subject human therapy evaluation immunopathology chemotherapy immunosuppressive intravenous administration kidney disorder chemotherapy longitudinal human study methylprednisolone nephritis prednisone systemic lupus erythematosus

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中文摘要
翻译
新患者被随机分配接受（i）每月IV- 环磷酰胺，（ii）每月IV甲泼尼龙，或（iii）两者。的 研究现在对新进入者关闭。进展为肾衰竭的速率， 正在评估重新治疗的要求和药物毒性。 自去年的报告以来，我们现在已经跟踪了另外23名患者 至少一年在这方面， 完成1年研究的整个患者组。（因为它花了5） 年的差异发生在以前的研究中，我们认为， 要使趋势出现，就必须采取后续行动]。
英文摘要
New patients have been randomized to receive (i) monthly IV- cyclophosphamide, (ii) monthly IV methylprednisolone, or (iii) both. The study is now closed to new entrants. Rate of progression to renal failure, requirements for re-treatment, and drug toxicities are being assessed. Since last year's report, we have now followed an additional 23 patients for at least one year. Clear-cut differences have yet to emerge for the entire group of patients completing 1 year of study. [Since it took > 5 years for differences to occur in prior studies, we believe that a longer follow-up is necessary for even trends to emerge].
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PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
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