课题基金 / 基金详情

MURINE AND HUMAN AUTOIMMUNITY

MURINE AND HUMAN AUTOIMMUNITY
鼠类和人类自身免疫
批准号:
3752101
负责人:
G M SHEARER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
该实验室已经确定,T辅助细胞(Th)的模式 在无症状、HIV血清阳性(HIV+)的患者中也可检测到功能障碍 在系统性红斑狼疮(SLE)患者中。 因此, SLE患者的免疫失调与 艾滋病毒阳性者。 为了研究其他可能的相似之处,我们有 检测了SLE患者和SLE样疾病小鼠的血清, 发现了识别HIV gp120的抗体的证据, HIV包膜的某些合成肽。 这些结果提供了进一步 SLE患者中类似免疫失调事件的证据, 感染艾滋病毒的人。
英文摘要
This laboratory has established that the pattern of T helper cell (Th) dysfunction seen in asymptomatic, HIV-seropositive (HIV+) is also detected in patients with systemic lupus erythematosus (SLE). Thus, there are certain similarities between the immune dysregulation of SLE patients and HIV+ individuals. To investigate other possible similarities, we have tested the sera of SLE patients and mice with SLE-like diseases, and have found evidence of antibodies that recognize the gpl2O of HIV, as well as certain synthetic peptides of HIV envelope. These results provide further evidence of similar immunodysregulatory events in SLE patients and individuals infected with HIV.
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会议论文
CELLULAR IMMUNE FUNCTION IN AIDS AND CANCER
CELL MEDIATED IMMUNITY TO HAPTEN MODIFIED SYNGENEIC LYMPHOCYTES IN MICE
DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS
SYNERGISTIC EFFECTS OF MURINE CYTOMEGALOVIRUS AND GRAFT-VERSUS-HOST REACTION
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