IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES

这个项目的目的是描述涉及到 调节丝虫病和非丝虫病状态下的免疫反应。 免疫调节研究已经研究了抗原特异性的现象 微丝状体缺乏症患者的无能表现为 对寄生虫抗原的增殖细胞频率降低，以及 产生抗增殖细胞因子IL-10和转化生长因子-β。 主要细胞因子的滤过性免疫斑块分析已经发展起来。 并被用来证明在人类蠕虫感染中 Th2、CD4+细胞的扩增。这些细胞的表型特征 Th2的CD4+细胞表现为CD45RO+人类白细胞抗原-DR+CD27-。潜在的 对某些寄生虫抗原的免疫反应的遗传基础是 目前正在研究中。

The purpose of this project is to delineate the mechanisms involved in regulating immune response in filarial and nonfilarial disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of a diminished frequency of proliferating cells to parasite antigen and of the production of the antiproliferative cytokines, IL-10 and TGF-beta. Filter immunoplaque assays for the major cytokines have been developed and used to demonstrate that in helminth infections of humans there is an expansion of Th2 CD4+ cells. The phenotypic characterization of these TH2 CD4+ cells has shown them to be CD45RO+ HLA-DR+ CD27-. The underlying genetic basis for the immune responses to certain parasite antigens is currently being studied.