OSTEOARTHRITIS AND AGING

骨关节炎（OA）是老年人最常见的风湿性疾病， 估计有4000万美国人有OA的放射性证据。 作为正在进行的巴尔的摩OA纵向研究的一部分， 老化（BLSA）我们提供了男性手部OA的放射学数据，并且 已经评估了代谢和生理 手OA的因素。 我们现在已经评估了明确的 在BLSA的422名女性中进行了手部OA的放射学检查，并证明， 随着年龄的增长，不正常的X光照片明显增加。 以下的女性 40岁以下的患者有< 1%的异常读数，从2010年开始增加。 40年代有25%的异常，继续在50年代（77%）和60年代（94%）， 70岁以上妇女中99%有X线异常。 在325名女性中， 40岁的估计脂肪量和分布是积极的， 与OA等级相关，而手部和手臂的骨量估计值与OA等级相关。 与OA分级呈负相关。 这些关联不存在， 解释了较高OA等级的年龄分布。 同样地， 血清胰岛素样生长因子-I水平与OA呈负相关 在115名年龄在22-86岁的妇女中， 当考虑到年龄时。 这些研究不支持 生理和代谢因素与手相关假说 女性OA，与其已知的年龄相关性无关。

Osteoarthritis (OA) is the most common rheumatic disease of the elderly, with 40 million Americans estimated to have radiological evidence of OA. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have presented data on radiographic hand OA in men, and have evaluated the possible association of metabolic and physiologic factors with hand OA. We have now evaluated the prevalence of definite radiographic hand OA in 422 women of the BLSA, and have demonstrated that there is a marked increase in abnormal radiographs with age. Women under 40 years of age had < 1% abnormal readings which increased starting in the 40's with 25% abnormal, continuing in the 50's (77%) and 60's (94%) with > 99% of the women over 70 having abnormal radiographs. In 325 women over the age of 40 estimates of fat mass and distribution were positively related to OA grade, while estimates of bone mass of the hand and arm were negatively related to OA grade. These associations were not present when the age distribution of the higher OA grades was accounted for. Similarly, serum levels of Insulin-like growth factor-I were inversely related to OA grade in 115 women aged 22-86, but this association also was not present when age was taken into account. These studies fail to support the hypothesis that physiologic and metabolic factors are associated with hand OA in women, independent of their known association with age.