IMMUNE RESPONSE OF HCV INFECTION

这是一个新启动的协作多阶段项目，需要调查 人和实验动物的免疫反应 感染人类丙型肝炎病毒。在最初阶段， 商业检测试剂盒将用于检测丙型肝炎病毒蛋白抗体 在已知的非甲非乙型肝炎患者血清中。这将提供 丙型肝炎病毒感染及其感染的血清学资料 与其他临床检测的关系。第二阶段 研究将集中在免疫显性的识别上 表位和中和表位。本研究这一阶段的范围 将是广泛和耗时的。该项目的第三阶段将 包括利用免疫反应的知识来制定预防措施 战略和了解这种病毒感染的致病性。 将特别注意免疫之间可能存在的关系 应答率和患者慢性化程度高。

This is a newly initiated collaborative multi-phase project to investigate the immune response in both human and experimental animals after the infection with the human hepatitis C virus. In the initial phase, the commercial testing kits will be used to detect antibodies to HCV proteins in the known non-A, non-B hepatitis patient sera. This will provide information on the serological data of hepatitis C virus infection and its relationship to other clinical determination. The second phase of the study will be concentrated on the identification of immune dominant epitopes and neutralizing epitopes. The scope of this phase of this study will be extensive and time consuming. The third phase of the project will encompass using the knowledge of immune response to develop preventive strategy and understanding the pathogenicity of this viral infection. Special attention will be paid to the possible relationship between immune response and the high chronicity in patients.