课题基金 / 基金详情

IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES

IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
丝虫病和非丝虫病的免疫调节和免疫识别
批准号：
3803110
负责人：
T B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3803110
关键词：
B lymphocyte Filarioidae T lymphocyte antibody formation antigen antibody reaction antimicroorganism antibody biological signal transduction filariasis helminthic antigen human subject immunoglobulin E immunoglobulin G immunoregulation leukocyte activation /transformation lymphokines microorganism immunology monoclonal antibody neutralizing antibody onchocerciasis tissue /cell culture

项目摘要

项目成果

T B NUTMAN的其他基金

相关文献

中文摘要
翻译
这个项目的目的是描述涉及到 调节丝虫病患者的体液和细胞反应 和其他疾病状态。免疫调节研究已经检查了 微丝虫病患者的抗原特异性无能现象 这种无能是增殖细胞频率降低的结果 对寄生虫抗原。寄生虫抗原驱动抗体的体外模型 生产重组淋巴因子和中和抗体 已经被用来理解调节抗体所需的信号 在分子水平上产生对寄生虫抗原的反应。
英文摘要
The purpose of this project is to delineate the mechanisms involved in regulating the humoral and cellular responses in patients with filariasis and other disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of a diminished frequency of proliferating cells to parasite antigen. In vitro models of parasite-antigen driven antibody production along with recombinant lymphokines and neutralizing antibodies have been used to understand the signals necessary to regulate antibody production in response to parasite antigen at a molecular level.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MOLECULAR DEFINITION OF FILARIAL ANTIGENS
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES