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ETIOLOGY AND PATHOGENESIS OF IDIOPATHIC INFLAMMATORY MYOPATHY IN HUMANS

ETIOLOGY AND PATHOGENESIS OF IDIOPATHIC INFLAMMATORY MYOPATHY IN HUMANS
人类特发性炎症性肌病的病因和发病机制
批准号：
3819298
负责人：
P H PLOTZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3819298
关键词：
autoantibody dermatomyositis disease /disorder classification human subject inflammation polymyositis serology /serodiagnosis

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中文摘要
翻译
特发性炎症性肌病（多发性/皮肌炎）是一种 肌肉炎性疾病，其特征是 出现自身抗体。 通过应用广泛的免疫学， 临床和流行病学观察，以大量（约150） 一组患者，我们已经开发出的子集的证据 患者强烈表明，这种疾病可以分为 分成不同病因的更有意义的组， 发病机制 到目前为止，抗Jo-1的患者群体 抗体和与信号识别肽的抗体是 在临床、流行病学和血清学上都不同， 彼此和其他病人的信息
英文摘要
ldiopathic inflammatory myopathy (poly/dermatomyositis) is an inflammatory disease of muscle in which characteristic autoantibodies occur. By applying a broad range of immunological, clinical, and epidemiological observations to a large (about 150) group of patients, we have developed evidence for subsets of patients which strongly suggest that the disease can be divided into more meaningful groups with different etiology and pathogenesis. So far, the groups of patients with anti-Jo-l antibodies and with antibodies to signal recognition peptide are clinically and epidemiologically as well as serologically distinct from each other and from other patients.
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会议论文
GENETIC METABOLIC MYOPATHIES--PHOSPHOFRUCTOKINASE/ACID MALTASE DEFICIENCY
IMMUNOPATHOGEN AUTOIMMUNE INFLAMMATORY MYOPATHIES--POLYMYOSITIS/DERMATOMYOSITIS
THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
VIRUSES IN THE INDUCTION OF AUTOANTIBODIES IN HUMANS AND MICE
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