EXERCISE-INDUCED CARDIAC ARRHYTHMIAS

我们比较了运动诱导的患病率和复杂性 慢性利尿剂单药治疗BLSA患者的心律失常 高血压组与正常血压对照组。虽然 运动性心律失常的患病率在 利尿剂治疗组(D)与对照组(C)分别为57%和38%，P 高于0.05，这一差异完全是由于高流行率 单纯性室性早搏(VEB)：44%对26%，p 而不是0.05。两组之间没有发现差异，在 常见的频繁或复杂的异位搏动。 1974至1984年间，80名BLSA受试者(占测试人数的6.9%) 发展频繁(任何一分钟超过10%的心跳) 室性异位搏动(VEB)或3次或3次以上VEB在 至少一次最大跑步机运动试验。那些正在发展中的 频繁或重复的VEB比其余受试者年龄大 63.8正负12.5对50.0正负16.1年，p小于0.0001。 在前一组中，缺血性ST段反应 只有11%的人观察到锻炼。在平均随访期内 在没有抗心律失常药物治疗的4.6年中，只有一年 心源性死亡和一例非致命性心肌梗死 发生了。探讨运动性脑损伤的机制 表面上健康的受试者出现复杂性室性心律失常， 我们比较了20例BLSA的复极时间，即QT间期 运动性非持续性心动过速受试者 20例正常人的心动过速(VT) 年龄和性别匹配，没有运动诱导的人 心律不齐。虽然在心率上没有差异，但 休息或在小组之间尽最大努力，那些有锻炼的人- 诱导性室性心动过速患者的QT间期较对照组延长(278 正负9对259正负6毫秒，p小于0.08)。鉴于 20名室性心动过速受试者中有12名未能将QT间期缩短25% 在20名对照中只有5人证实了这一发现，p<0.05。 (以前：最大限度跑台运动的并发症 明显正常的受试者)

We compared the prevalence and complexity of exercise-induced arrhythmias in BLSA subjects on chronic diuretic monotherapy of hypertension with that in normotensive control group. Although the prevalence of exercise induced arrhythmias was higher in the diuretic treated group (D) that in controls (C) 57% vs 38%, p less than .05, this difference was due entirely to the high prevalence of simple ventricular ectopic beats (VEB): 44% versus 26%, p less than .05. No difference between the groups was found in the prevalence of frequent or complex ectopic beats. Between 1974 and 1984, 80 BLSA subjects (6.9% of those tested), developed frequent (more than 10% of beats in any minute) ventricular ectopic beats (VEB) or runs of 3 or more VEB on at least one maximal treadmill exercise test. Those developing frequent or repetitive VEB were older than the remaining subjects 63.8 plus/minus 12.5 vs 50.0 plus/minus 16.1 yr, p less than .0001. Within the former group, an ischemic ST segment response to exercise was observed in only 11%. Over a mean follow-up period of 4.6 years without anti-arrhythmic drug therapy, only one cardiac death and one non-fatal myocardial infarction have occurred. To investigate the mechanisms for exercise-induced complex ventricular arrhythmias in apparently healthy subjects, we compared repolarization time, i.e QT intervals, in 20 BLSA subjects with exercise induced nonsustained ventricular tachycardia (VT) with those of 20 normal BLSA individuals matched for age and sex, who were free of exercise-induced arrhythmias. Although no difference in heart rate was present at rest or at maximal effort between groups, those with exercise- induced VT had longer QT intervals then the controls (278 plus/minus 9 vs 259 plus/minus 6 msec, p less than .08). Whereas 12 of 20 VT subjects failed to shorten their QT interval by 25% only 5 of 20 controls demonstrated this finding, p less than .05. (Formerly: Complication of Maximal treadmill Exercise in Apparently Normal Subjects)