MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS

关于地下水污染物对健康影响的研究一直在进行 主要以癌症为终点。在目前的研究中，骨骼 监测了暴露于0、1、5和10%甲苯的小鼠的骨髓参数。 饮用水中的化学混合物可持续17天或最多32周。这个 由25种常见的地下水污染物组成的混合物 环保局调查确定的有毒废物堆放场附近。小鼠暴露于5和 10%的原液在15.5周内显示抑制作用 粒-巨噬系祖细胞和红系祖细胞 或对体重、组织病理学和外周血细胞计数无影响。 小鼠被允许恢复10周，在此期间它们获得了 身体照射。以前接受化学处理的小鼠对 照射比未经处理的对照组要好。此外，这两个因素的协同效应 通过持续的化学暴露证明了化学和辐射。 进行多次照射。在以下情况下，这种影响变得更加明显 多次照射后祖细胞恢复较多 慢慢地。因此，接触化学物质会造成严重的残留骨髓损伤。 这在常规血液学或病理学检查中并不明显 技术，但可以通过随后的辐射来证明。这些 结果表明，长期暴露在高度污染的地下水中 可能会给造血干细胞带来微妙的风险。

Studies concerning the health effects of groundwater contaminants have been focused primarily on cancer as an endpoint. In the present studies, bone marrow parameters were monitored in mice exposed to 0, 1, 5, and 10% of a chemical mixture in drinking water for 17 days or up to 32 weeks. The mixture consisted of 25 common groundwater contaminants frequently found near toxic waste dumps as determined by EPA surveys. Mice exposed to 5 and 10% of stock solution for 15.5 weeks showed suppression of granulocyte-macrophage progenitor cells and erythroid precursors with few or no effects on body weight, histopathology and peripheral blood counts. Mice were allowed to recover for 10 weeks at which time they received whole body irradiation. Previously chemical-treated mice were more sensitive to irradiation than untreated controls. Furthermore, synergistic effects of chemical and irradiation were demonstrated by continuing chemical exposure with multiple irradiation. The effect became more pronounced following multiple irradiation and the recovery of progenitor cells occurred more slowly. Thus, chemical exposure caused a significant residual marrow damage that was not apparent with routine hematological or pathological techniques, but could be demonstrated by subsequent irradiation. These results suggest that long-term exposure to highly contaminated groundwater may present a subtle risk to the hematopoietic stem cells.