OXIMES RESEARCH PROJECT

肟被用于包括中间体在内的各种应用中。 用于生产化学品和农药，阻断剂在 聚合物工业，金属工业中的螯合剂，燃料添加剂，染料， 等，并作为水和废物处理的杀生剂。代表 来自这类化学品的化合物被NCI提名是因为他们的 毒性和潜在的致癌性尚未得到很好的表征。 在一份合同中启动了对环己酮肟和丁酮肟的研究 实验室评估F344大鼠和B6C3F1小鼠14天后的毒性 以及90天接触饮用水中的化学物质。这些变量 将被测量的包括体重，器官重量，临床体征 毒性，在完成比较代谢研究后。在……里面 此外，对环己酮的影响进行了初步研究 肟类对乙二醇烷基醚的毒性正在进行中，因为这种肟类 干扰酒精新陈代谢。

The oximes are used in a variety of applications that include intermediates for the production of chemicals and pesticides, blocking agents in the polymer industry, chelator in the metal industry, additives in fuels, dyes, etc., and as biocides for water and waste treatment. Representative compounds from this class of chemicals were nominated by NCI because their toxicity and potential carcinogenicity had not been well characterized. Cyclohexanone oxime and butanone oxime studies were initiated in a contract laboratory to evaluate toxicity in F344 rats and B6C3F1 mice after 14 day and 90 day exposure to the chemicals in the drinking water. Variables that will be measured include body weight, organ weights, clinical signs of toxicity, after the completion of comparative metabolism studies. In addition, preliminary investigations of the influence of cyclyohexamone oxime on glycol alkyl ether toxicity are underway, because this oxime interferes with alcohol metabolism.