MOLECULAR SPECTROSCOPY INSTRUMENTATION

请拨资金用于购买分子光谱仪 仪器仪表 该仪器包括CD分光偏振计、 高分辨率紫外/可见分光光度计，停流光谱仪， 和傅里叶变换红外（FTIR）光谱仪。 所有这些 仪器将被安置在埃默里大学化学系， 有效和全面的分析。 的研究 11个NIH项目将通过使用这种仪器得到加强。 那里 在主要用户群中有八名NIH资助的研究人员。 未成年人 用户群包括三位年轻的助理教授，他们正在追求 从事生物医学研究。 主要用户和次要用户都在追求 诸如药物与蛋白质的相互作用等多样化的生物医学研究， 抗癌药物的作用机制，辅酶B12依赖 酶促过程，金属抗HIV药物开发，作用机制 具有共价结合黄素的酶，肾显像剂中的Tc-99m， 有机合成应用于抗癌药物、多肽抑制剂、 蛋白激酶，促有丝分裂生长因子的构象分析， DNA结构特异性探针与质谱新方法 蛋白质和肽测序。 建议的仪器是必不可少的 这些研究项目。

Funds are requested for the purchase of molecular spectroscopy instrumentation. This instrumentation includes a CD spectropolarimeter, a high resolution uv/visible spectrophotometer, a stopped-flow spectrometer, and a Fourier transform infrared (FTIR) spectrometer. All of these instruments will be housed in the Emory University Chemistry Department in the interest of efficient and comprehensive analysis. The research of eleven NIH programs will be enhanced by use of this instrumentation. There are eight NIH funded investigators in the major users group. The minor users group include three young assistant professors who are pursuing careers in biomedical research. The major and minor users are pursuing such diverse biomedical research as the interaction of drugs with proteins, the mechanism of action of anticancer drugs, co-enzyme B12 dependent enzymic processes, metalloanti-HIV drug development, mechanism of action of enzymes with covalently bound flavins, Tc-99m in renal imaging agents, organic synthesis applied to anticancer drugs, peptide inhibitors of protein kinases, conformational analyses of mitogenic growth factors, specific probes of DNA structure and novel methods of mass spectroscopic protein and peptide sequencing. The proposed instrumentation is essential to these research projects.