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THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM

THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM
免疫系统蛋白质的三维结构
批准号：
3917785
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3917785
关键词：
X ray crystallography antigen antibody reaction antigens binding proteins computer simulation conformation crystallization galactans haptens immunoglobulin structure isomorphous substitution laboratory mouse lysozyme molecular biology monoclonal antibody myeloma globulin protein structure

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中文摘要
翻译
1)单克隆抗体HyHEL-5 Fab的结构， 与其抗原溶菌酶复合，已在三个- 尺寸通过X射线衍射分析。 这个结构现在 几乎完全被提炼成两种晶体形式。 2)单克隆抗体HyHEL-10 Fab的结构也具有 已经确定，几乎完全完善。 的比较 这些结构与第三个这样的复合物一起确定 在其他地方，使我们能够作出一些一般性的声明， 抗体抗原相互作用。
英文摘要
1) The structure of the monoclonal antibody, HyHEL-5 Fab, complexed with its antigen, lysozyme, has been determined in three- dimensions by X-ray diffraction analysis. This structure was now been almost completely refined in two crystal forms. 2) The structure of the monoclonal antibody HyHEL-10 Fab has also been determined and almost completely refined. A comparison of these structures together with a third such complex determined elsewhere has enabled us to make some general statements about antibody antigen interactions.
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