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MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS

MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS
饮用地下水污染物混合物引起的小鼠骨髓毒性
批准号：
3918652
负责人：
H L HONG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3918652
关键词：
biological models environmental toxicology hematopoiesis hematopoietic stem cells industrial waste laboratory mouse toxin metabolism water pollution

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中文摘要
翻译
关注化学物质对健康的潜在不良影响 受污染的地下水已存在多年。 在 目前的研究监测了女性的骨髓参数 B6C3F1小鼠暴露于饮用水中的化学混合物17 天或长达32周。 该混合物由25种常见的 地下水污染物经常出现在有毒废物倾倒场附近， 根据EPA的调查。 这些实验的目的 比较不同时间段的血液毒性 并确定残余损害是否可能 在造血功能衰竭的时候， 干细胞持续受损或接近恢复。
英文摘要
Concern over the potential adverse health effects of chemically contaminated groundwater has existed for many years. In the present studies bone marrow parameters were monitored in female B6C3F1 mice exposed to a chemical mixture in drinking water for 17 days or up to 32 weeks. The mixture consisted of 25 common groundwater contaminants frequently found near toxic waste dumps, as determined by EPA surveys. The purpose of these experiments were to compare the hematopoisis among the different time courses of exposure and to determine whether residual damage could be demonstrated by subsequent radiations at a time when hematopoietic stem cells sustained injury or nearly recovered.
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会议论文
EFFECTS OF GLYCOL ETHERS ON BONE MARROW PARAMETERS
RELEVANCE OF CHEMICALLY INDUCED HEMANGIOSARCOMAS IN B6C3F1 MOUSE
DETECTION OF ONCOGENE ALTERATIONS IN MICE INDUCED BY CHLOROPRENE
RELEVANCE OF CHEMICALLY INDUCED FORESTOMACH NEOPLASMS IN B6C3F1 MOUSE
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