PANCREATIC NODULE TRANSPLANTATION

DTRT与大学有三项合作协议可供研究 玉米油对小鼠胰腺外分泌功能的影响 那只老鼠。他们的部分研究将要求对老鼠进行断奶 用玉米油长达两年的时间产生增生和 F344大鼠的腺瘤。由于大多数大学都没有 啮齿动物长期重复灌胃的能力，建立DTRT 与EG&G Mason签订合同，给150只F344大鼠灌胃1000万玉米 油/公斤，每周5天，共100周。为了确定 胰腺外分泌病变的数目、大小和可移植性 雄性F344大鼠灌胃75-100次玉米油 几周后，大鼠被解剖，胰腺称重，结节 青年男性F344移植结节的计数和部分 接受者(一个结节/四个接受者)。如果发现损伤， 他们将被移植到四个接受者体内，最多十个人 在三个月后，接受者将被杀死并 检查过了。如果看到增长，再进行一次为期三个月的移植。这个 移植部分结节并进行组织学检查的能力 REST可能有助于验证我们当前的分类方案。这个 结果表明，移植后几乎没有生长。 到肾胶囊。

DTRT has three cooperative agreements with universities to study the effects of corn oil administration on the exocrine pancreas of the rat. Part of their studies would require that rats be gavaged with corn oil for up to two years to produce hyperplasia and adenomas in F344 rats. Since most universities do not have the capability for repeated long term gavage in rodents, DTRT set up a contract with EG&G Mason to gavage 150 F344 rats with 10 ml. corn oil/kg 5 days a week for 100 weeks. In order to determine the number, size and transplantability of exocrine pancreas lesions in male F344 rats that have received corn oil by gavage for 75-100 weeks, the rats were necropsied, the pancreas weighed, nodules counted and portions of nodules transplanted to young male F344 recipients (one nodule/four recipients). If lesions are found, they will be transplanted into four recipients for up to ten lesions and at three months the recipients will be killed and examined. If growth is seen, one more three-month transplant. The ability to transplant part of a nodule and have histology on the rest may help validate our current classification scheme. The results indicate there is little or no growth on transplantation to the kidney capsule.