Dengue virus NS1 protein as a mediator of pathology

登革热病毒在热带世界是一个日益严重的问题，估计每年有超过3亿人感染。严重的登革热疾病可能导致危及生命的出血和休克。我们的项目调查了这种疾病的病理基础。我们发现，一种名为NS1的病毒蛋白与免疫细胞上的受体结合，导致炎性蛋白的产生，从而促进血管渗漏。我们将在疾病模型中研究阻止这一点的药物。

Dengue virus is an increasing problem in the tropical world, with estimated infection of more than 300 million people annually. Severe dengue disease can cause life-threatening bleeding and shock. Our project investigates the basis for the pathology of the disease. We have found that a viral protein termed NS1 binds to a receptor on immune cells and leads to production of inflammatory proteins which can promote vessel leakage. We will investigate drugs blocking this, in a disease model.