DERMAL ABSORPTION OF DIETHANOLAMINE AND TRIETHANOLAMINE IN RATS AND MICE

二乙醇胺(DEA)和三乙醇胺(TEA)被广泛使用 在化妆品中，如面霜、洗面奶和洗发水。 在美国国立卫生研究院进行的一项为期14天的重复剂量研究中 毒理学计划，茶对皮肤的毒性更大 经皮给药后的大鼠比小鼠。皮肤吸收 在F344大鼠和B6C3F1小鼠身上进行了TEA的研究。 有助于解释物种对这种化学物质的敏感性差异。 夹闭雄性大鼠和小鼠肩关节间区， 经过筛选的环安装在预定的化学物质位置上 申请。14C-TEA溶解于丙酮，在 组织帽适用于大鼠和小鼠。8点采集了血样。 给药后48小时内的时间点，氧化成二氧化碳， 并用液体闪烁计数法测定~(14)C。 尿液、粪便、组织帽和皮肤切片中的放射性 并对应用部位进行统计。茶被吸收了 大鼠和小鼠经皮给药后， 小鼠的吸收更大，化学物质的水平保持不变 用药部位对大鼠的影响较大。类似 DEA在大鼠和小鼠皮肤吸收的比较研究 都是有计划的。

Diethanolamine (DEA) and triethanolamine (TEA) are widely used in cosmetic products such as creams, skin cleaners, and shampoos. In a 14-day repeated-dose study conducted by the National Toxicology Program, TEA was found to be more toxic to the skin of rats than mice after dermal application. Dermal absorption studies of TEA in F344 rats and B6C3F1 mice were initiated to help explain species differences in sensitivity to this chemical. The interscapular area of male rats and mice were clipped, and screened rings were mounted over the intended site of chemical application. 14C-TEA dissolved in acetone was applied within the tissue caps to rats and mice. Blood samples were taken at eight time points over a 48 hour period after dosing, oxidized to CO2, and assayed for 14C by liquid scintillation counting. Radioactivity in urine, feces, tissue caps and skin sections from the site of application were also counted. TEA was absorbed after dermal application in rats and mice; however, the rate of absorption was greater in mice and the level of chemical retained at the site of application was greater in rats. Similar comparative dermal absorption studies of DEA In rats and mice are planned.