CELLULAR BIOCHEMISTRY STUDIES ON CHEMICAL SELECTED FOR EVALUATION BY NTP

无机或有机金属和金属络合物的影响是 特别令人感兴趣的是它们在饮酒中的普遍程度 水和工业过程，用作抗癌成分 药物及其不同的靶器官毒性。毒理学 正在对各种选定的金属盐进行研究，以 支持和推广在合同测试设施中获得的结果。 测量血液和靶器官水平以确定 金属残留物的处置和稳态浓度。 细胞生化反应提供了敏感的指标 靶器官毒性通常先于临床症状或 病理的微观证据。例子包括水银 胸腺T细胞糖酵解酶的抑制作用 具有免疫毒性和镍抑制作用的己糖 粒细胞/巨噬细胞干细胞中的单磷酸分流酶 骨髓中的细胞与骨髓毒性有关。进一步 二氯二茂钛、钠的研究正在进行 铬酸盐、铬酸锌、铬酸钾、羰基铬和 亚铁氰化铁铵。

The effect of inorganic or organic metals and metal complexes is of particular interest because of their prevalence in drinking water and industrial processes, use as constituents in anticancer drugs, and their diverse target organ toxicities. Toxicological studies of various, selected metallic salts are being conducted to support and extend the results obtained at contract test facilities. Blood and target organ levels are measured to determine the disposition and steady state concentrations of the metal residues. Cellular biochemical responses provided sensitive indices of target organ toxicity that often preceeded clinical signs or microscopic evidence of pathology. Examples included mercury inhibition of glycolytic enzymes in thymic T-cells in association with immunotoxicity, and nickel inhibition of hexose monophosphate shunt enzymes in granulocyte/macrophage stem cells from bon marrow in association with myelotoxicity. Further studies are underway with titanocene dichloride, sodium chromate, zinc potassium chromate, chromium carbonyl, and ferric ammonium ferrocyanide.