REGIONAL CEREBRAL CIRCULATION AND METABOLISM

脱氧葡萄糖法定量测定 在离散功能和局部葡萄糖消耗率 意识或麻醉的大脑的结构成分 实验动物在这个实验室里发展了10多个 年前 在该方法中，（14 C）脱氧葡萄糖被用作 通过己糖激酶步骤的葡萄糖通量的示踪剂;产物， （14 C）脱氧葡萄糖-6-磷酸，通过定量测定来测量。 放射自显影 该方法继续用于研究 局部能量代谢的改变， 生理学、药理学和数量有限的 病理状态。 它适用于更广泛的病理性 条件正在延长和特殊的时间限制， 可以存在于该方法的适用于人类的适应中， 接受（18 C）氟脱氧葡萄糖和PET检查的受试者， 考察

The deoxyglucose method for the quantitative determination of rates of local glucose consumption in the discrete functional and structural components of the brain of conscious or anesthetized laboratory animals was developed in this laboratory over 10 years ago. In this method (14C)deoxyglucose is employed as a tracer for glucose flux through the hexokinase step; the product, (14C)deoxyglucose-6-phosphate, is measured by quantitative autoradiography. The method continues to be used to study alterations in local energy metabolism in a variety of physiological, pharmacological and a limited number of pathological states. Its suitability to a wider range of pathologic conditions is being extended and special time constraints which may be present in the method's adaptation for use in human subjects with (18C)fluorodeoxyglucose and PET have been examined.