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IMMUNOSUPPRESSION AND PLASMAPHERESIS IN GOODPASTURE'S SYNDROME

IMMUNOSUPPRESSION AND PLASMAPHERESIS IN GOODPASTURE'S SYNDROME
Goodpasture 综合征中的免疫抑制和血浆去除术
批准号：
3964768
负责人：
J E BALOW
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3964768
关键词：
Goodpasture's syndrome autoantibody autoimmune disorder drug adverse effect glomerulonephritis human subject human therapy evaluation immunopathology chemotherapy immunosuppression immunosuppressive kidney disorder metabolism disorder plasmapheresis

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中文摘要
翻译
古德帕斯普雷综合征的特征通常是进展迅速 抗肾小球基底膜自身抗体致肾小球肾炎 膜(抗GBM)。这项研究将检查血浆置换是否 显著提高标准免疫抑制药物的疗效 治疗这种疾病的方法。患者将被随机分配到药物治疗 单独治疗或药物加血浆置换，直到抗-GBM水平达到 检测不到。将对有利结果的数量进行比较 在6个月的研究结束时，比较这些疗法的并发症发生率。 维拉帕米的疗效、并发症及费用平衡分析 血浆置换治疗古德帕斯普雷综合征将更容易 根据这项研究的结果。
英文摘要
Goodpasture's Syndrome is usually characterized by rapidly progressive glomerulonephritis due to autoantibodies against glomerular basement membrane (anti-GBM). This study will examine whether plasmapheresis significantly improves the results of standard immunosuppressive drug treatment of this disease. Patients will be randomly allocated to drug treatment alone or drugs plus plasmapheresis until anti-GBM levels are undetectable. Comparison will be made of the numbers of favorable outcomes and complication rates of these therapies at the end of 6 months of study. Analysis of the balance of efficacy, complications and expense of plasmapheresis in treatment of Goodpasture's syndrome will be facilitated by the results of this study.
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