ISOLATION IN CELL CULTURE AND SEROTYPIC CHARACTERIZATION OF HUMAN ROTAVIRUSES

这个项目的目的是直接在细胞培养中培养各种 来自不同地理区域的人和其他动物轮状病毒株 和群体，以便定义血清型多样性和相似性 选择和开发潜在的候选疫苗。新成立的 血清4型轮状病毒已被证明在急性呼吸道感染中起病原学作用。 胃肠炎，其全球分布也被记录在案。它 研究表明，在“家庭”分类之间没有相关性 基于RNA-RNA杂交和基于病毒的血清型鉴定 中和。从其他实验室分离的两株人类轮状病毒， 据说代表了新的血清型，以及一种牛轮状病毒 疑似属于2型的分离株正在 在我们的实验室进行调查。

This project is designed to cultivate, directly in cell cultures, a variety of human and other animal rotavirus strains from diverse geographical areas and populations in order to define serotypic diversity and similarity and to select and develop potential vaccine candidates. The newly established serotype 4 rotaviruses have been shown to play an etiological role in acute gastroenteritis, and its worldwide distribution was also documented. It was shown that there is no correlation between "family" classification based on RNA-RNA hybridization and serotype designation based on neutralization. Two human rotavirus isolates from other laboratories, which are said to represent new serotypes, as well as a bovine rotavirus isolate which is suspected of belonging to serotype 2 are under investigation in our laboratory.