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MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS
胸腺源性 (T) 抑制细胞和增强细胞的作用方式
批准号：
4688365
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4688365
关键词：
B lymphocyte Streptococcus pneumoniae affinity chromatography antibody formation antibody specificity bacterial antigens bacterial genetics bacterial polysaccharides cell transformation cyclophosphamide helper T lymphocyte hybrid cells hybridomas immune tolerance /unresponsiveness immunogenetics immunoglobulin genes immunoregulation membrane activity microorganism immunology monoclonal antibody suppressor T lymphocyte

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中文摘要
翻译
骨髓来源的抗体形成细胞前体(B细胞)的转移 细胞)，取自III型肺炎球菌多糖免疫的小鼠 (SSS-III)导致抑制和放大T细胞的激活 控制受体小鼠抗体反应的大小， 随后用SSS-III免疫。转让的乙方的优先处理 含有过量酶(多糖解聚合酶)的细胞能够 水解SSS-III不会改变这些细胞的激活能力 调节性T细胞。这些发现表明，脑细胞的激活 免疫B细胞的调节性T细胞不受残存抗原的介导 被转移细胞的表面。
英文摘要
The transfer of bone marrow-derived precursors of antibody-forming cells (B cells) from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess of an enzyme (polysaccharide depolymerase) capable of hydrolyzing SSS-III, does not alter the capacity of these cells to activate regulatory T cells. These findings indicate that the activation of regulatory T cells by immune B cells is not mediated by residual antigen on the surface of transferred cells.
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REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
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