ROLE OF HEPATITIS C VIRUS IN HEPATOCELLULAR CARCINOMA

近年来，肝细胞癌的发病率呈上升趋势。 在日本大幅增加。来自日本和一些欧洲国家的数据 各国建议，那里的氟氯烃可能经常与 丙型肝炎病毒(HCV)。与生活在日本的日本人相比， 来到夏威夷的日本移民的后代还没有经历过 近年来，肝癌的发病率大幅上升。至 评估乙肝病毒和丙型肝炎病毒在夏威夷和澳大利亚肝癌患者中的作用 将结果与日本发表的肝细胞癌患者报告进行比较，a 从1967年到1970年，5924名日裔美国男性接受了检查。 到1992年，24例肝细胞癌(肝癌)病例被 组织学上在这组人中得到了证实。乙肝表面 15/24例(62%)肝细胞癌患者中检测到抗原，而72例中有2/72例(3%)。 对照组(优势比，58.3；95%可信区间，10.0-205.5)。无 只有一名对照组的患者有肝炎抗体 C病毒。这项研究表明，肝细胞癌与 患有乙肝病毒感染的癌症，但不患有丙型肝炎 夏威夷日裔患者中的病毒感染情况。

In recent years the incidence of hepatocellular carcinoma (HCC) has increased substantially in Japan. Data from Japan and some European countries suggest that HCCs there may be associated frequently with the hepatitis C virus (HCV). In contrast to Japanese who live in Japan, the descendants of Japanese immigrants to Hawaii have not experienced a substantial increase in the incidence of HCC in recent years. To evaluate the roles of HBV and HCV among HCC patients in Hawaii and to compare the results to published reports of HCC patients in Japan, a cohort of 5924 Japanese-American men were examined between 1967 to 1970. By 1992, 24 incident cases of hepatocellular carcinoma (HCC) were histologically confirmed in this group of men. Hepatitis B surface antigen was detected in 15/24 (62%) HCC cases compared with 2/72 (3%) controls (odds ratio, 58.3; 95% confidence interval, 10.0-205.5). None of the cases and only one of the controls had antibody to the hepatitis C virus. This study demonstrates a strong association of hepatocellular carcinoma with hepatitis B virus infection, but not with hepatitis C virus infection among patients of Japanese ancestry in Hawaii.