TOXICOKINETIC AND BIOCHEMICAL MODELING OF HAZARDOUOS AGENTS

工作总结：该项目旨在描述以下参数 外来物质的剂量、分布、代谢和消除。 这些信息有助于毒物学的设计和解释 研究和加强低剂量外推的科学基础 对人类的威胁。此外，生物现实的生物数学 模型提供了一种严密的结构来制定和测试假设 环境危害的作用机制。毒物动力学模型可以 也要适应不同的暴露途径和给药方案 能够适应导致个体间差异的因素。 在过去的一年里，已经建立了毒物动力学模型， 部分开发的或扩展的几种化学品，包括 扑草酮及其代谢物苯巴比妥、异戊二烯、异丁烯 1，3-丁二烯，TCDD，艾滋病药物单独或组合，褪黑素， 以及吸入汞蒸气在怀孕大鼠体内的处置和 新生儿。

Summary of Work: This project is designed to characterize parameters of dose, distribution, metabolism, and elimination of xenobiotic materials. This information can aid in the design and interpretation of toxicology studies and to strengthen the scientific basis for low-dose extrapolation of risk to humans. Furthermore, biologically realistic biomathematical models provide a rigorous structure to formulate and test hypotheses on mechanisms of action of environmental hazards. Toxicokinetic models can also be adapted to different routes of exposure and dosage regimens and can accomodate factors that contribute to interindividual variabilities. During the past fiscal year, toxicokinetic models have been created, partially developed, or expanded upon for several chemicals, including primidone and its metabolite phenobarbital, isoprene, isobutene, 1,3-butadiene, TCDD, AIDS drugs singly and in combinations, melatonin, and the disposition of inhaled mercury vapor in pregnant rats and neonates.