HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION

人工氧载体的研制及其在体内的应用 已知和可控的特征提供了一种新的方法 不同组织对氧的吸收、输送和利用的探讨 纸巾。我们将把重点放在人工产品的生产上 物理化学高度可控的血红蛋白基氧载体 和功能特性，并测试它们对特定动物的影响 模特们。这是一项高度跨学科的努力，涉及到分子 模拟、结晶学、基因工程、化学合成、 肾功能测试和脑生理学检查。该计划的战略 包括两个主要组成部分：分子设计和体内应用。

The development and application in vivo of artificial oxygen carriers of known and controllable characteristics offers a new approach to the exploration of uptake, delivery and utilization of oxygen by the various tissues. We will focus our efforts on the production of artificial hemoglobin-based oxygen carriers with highly controlled physico-chemical and functional properties, and test their effects on specific animal models. It is a highly interdisciplinary effort which involves molecular simulations, crystallography, genetic engineering, chemical synthesis, renal function tests and brain physiology. The strategy of the program includes two main components: Molecular design and in vivo applications.