STRUCTURE OF CTLA 4, T CELL CO STIMULATORY FACTOR

MHC抗原呈递的结构基础代表了以下之一： 免疫学的主要焦点。 我们现正研究 参与T细胞识别的T细胞分子 旨在了解规则，其中？？T细胞受体 分子与MHC分子中结合的肽相互作用， 随后的事件，直接T细胞活化。 除了有 MHC和T细胞受体，一些蛋白质如CTLA-4和B7 对调节T细胞反应至关重要。 我们准备了 晶体的共刺激因子CTLA-4，并已收集 X9 B至2.0E分辨率下的出色数据。 我们目前正在使用 在X9 B站出色的可调谐性，以解决这种结构， 使用常规重原子衍生物和硒代甲硫氨酸的MAD 替代。

The structural basis of MHC antigen presentation represents one of the major focuses of immunology. We are currently pursuing studies on molecules of the T cell that are involved in T cell recognition directed at understanding the rules by which the ?? T cell receptor molecules interact with the peptide bound in the MHC molecule and the subsequent events that direct T-cell activation. In addition to the MHC and T-cell receptor, a number of proteins such as CTLA-4 and B7 are essential for modulating the T-cell response. We have prepared crystals of the co-stimulatory factor CTLA-4 and have collected excellent data at X9B to 2.0E resolution. We are currently using the outstanding tunability at the X9B station to solve this structure by MAD using conventional heavy atom derivatives and selenomethionine substitution.