CHARACTERIZATION OF OPTICAL FIBER PROBES FOR IN VIVO RAMAN SPECTROSCOPY

活体拉曼光谱需要使用光纤探头 用于激光传输和收集返回的拉曼信号。 石英光纤中产生的荧光和拉曼背景 阻碍了生物组织样品的拉曼光谱测量 活着。我们正在开发和评估各种光纤探头 其中集成了激光带通滤光片和截止滤光片。 激励光纤中集成的介质带通滤波器 消除光纤中生成的背景，只允许 激发光照亮组织。电介质断路器 包含在收集光纤中的滤光片阻挡激光 从进入光纤，并且仅通过拉曼散射光 纸巾散发出来的。我们正在与Visionex和 目前正在评估他们探测器的性能。参数，如 如传输波长、滤光片的效率、程度 其光纤背景被抑制，并且还 正在对这些用于临床测量的兼容性进行评估。

In Vivo Raman spectroscopy requires use of optical fiber probes for laser light delivery and collection of return Raman signals. Fluorescence and Raman background generated in the silica fibers hinder measurement of Raman spectra from biological tissue samples in vivo. We are developing and evaluating various optical fiber probes in which laser band pass filter and cut-off filters are incorporated. Dielectric band-pass filter incorporated in the excitation fiber eliminates background generated in the fiber and allow only the excitation light to illuminate the tissues. A dielectric cut-off filter incorporated in the collection fibers blocks the laser light from entering the fiber and passes only the Raman scattered light emitted by tissues. We are working closely with Visionex and currently evaluating the performance of their probes. Parameters such as the transmission wavelength, efficiency of the filters, the extent to which the fiber background is suppressed, and also the compatibility of these for clinical measurements are being evaluated.