Core--Analytical

据报道多酚化合物对骨质疏松症、选定的癌症、动脉粥样硬化和认知障碍具有保护作用。为了促进这些问题的工作，一个实验室联盟的专业知识将通过这个分析核心，生物分析系统（AMS）将提供化合物分析，以保证植物身份，剂量，纯度，溶解特性，稳定性和批次变异性。他们还将进行方法开发和方法验证研究，以加快研究项目的工作，并对植物的母体化合物和代谢物进行化学分析加速器质谱（AMS）设施将开发和14 C研究植物的组成和代谢，41 Ca研究选定的植物衍生物对骨骼的影响。他们还将积极探索提高样品制备能力和加速器质谱研究能力的方法。此外，他们将通过一个外展计划为AMS的潜在用户/合作者提供指导。核心的行为/临床部分由位于两个地点的实验室组成。西拉斐特普渡校区包括人类感官研究实验室和人类性能和代谢实验室以及生物化学实验室。这些资源将支持所有研究活动，包括测量身体组成、能量消耗、心理指数、摄食行为和选定的生物样本分析。第二个临床研究中心位于印第安纳波利斯的印第安纳州大学医学院，将为拟定研究提供综合临床研究中心（GCRC）的全部资源。通过与项目1的合作，该部分还将探索具有雌激素特性的多酚化合物对食欲，选定的心理指数，化学感觉功能，身体成分和能量平衡的影响。这一行为/临床部分还将开发一个关于多酚化合物对健康影响的累积知识的注释网页。

Polyphenolic compounds reportedly hold protective effects against, osteoporosis, selected cancers, atherosclerosis and cognitive impairment. To facilitate work on these issues, the expertise of a consortium of laboratories will be available through this Analytical Core, Bioanalytical Systems (AMS) will provide compound analysis to guarantee botanical identity, dose, purity, dissolution properties, stability and batch variability. They will also conduct method development and method validation studies to expedite work in the research projects and conduct chemical analysis for both the parent compound and metabolites of botanicals The Accelerator mass spectrometry (AMS) facility will develop and 14C to study the composition and metabolism of botanicals and 41Ca to study the effect of selected botanical derivatives on the skeleton. They will also actively explore methods to increase sample preparation capability and capacity for accelerator mass spectrometry studies. Further, they will provide instruction to potential users/collaborators for AMS through an outreach program. The behavioral/clinical component of the Core is comprised of laboratories located at two sites. The West Lafayette Purdue Campus site includes the Laboratory for Human Sensory Studies and Human Performance and Metabolism Laboratory as well as a biochemistry laboratory. These resources will support all research activities involving measurement of body composition, energy expenditure, psychological indices, ingestive behavior and selected analyses of biological samples. The second site for clinical studies is located in the Indiana University School of Medicine in Indianapolis University School of Medicine in Indianapolis where the full compliment of resources of the General Clinical Research Center (GCRC) will be available for the proposed studies. Through a collaboration with Project 1, this component will also explore the effects of polyphenolic compounds with estrogenic properties on appetite, selected psychological indices, chemosensory function, body composition and energy balance. This behavioral/clinical component will also develop an annotated web page of the accumulated knowledge on the health effects of polyphenolic compounds.