HUMAN EXPOSURE TO HALOGENATED AROMATIC COMPOUNDS

在北卡罗来纳州对青春期的跟踪研究中，青春期男孩的身高随着胎盘中DDE的暴露而增加，根据身高调整后的体重也是如此。哺乳期暴露于DDE没有明显影响；经胎盘或哺乳期暴露于多氯联苯也没有明显影响。这对男孩达到青春期状态的年龄没有影响。经胎盘接触多氯联苯或DDE较高的女孩有提前成熟的趋势，但差异不显著。经胎盘接触多氯联苯的女孩身高比其他女孩重5.4公斤，但只有当分析限于白人女孩时，差异才显著。1979年，台湾有2000多人被热降解的多氯联苯中毒。我们已经证明，经过13年的随访，幸存者的非恶性肝病死亡率有所增加；然而，他们还没有表现出肝癌的过度，1969年日本一次类似中毒的幸存者也出现了这种情况。我们继续关注这一群体，包括中毒母亲所生的孩子。在台湾，我们正在开始设计一项临床和内分泌学研究，研究对象是处于青春期的女孩，当她们的母亲被多氯联苯/多氯二苯并呋喃中毒时，她们正在子宫中。

In the North Carolina follow up study of puberty, height of boys at puberty increased with transplacental exposure to DDE, as did weight adjusted for height. Lactational exposure to DDE had no apparent effects; neither did transplacental or lactational exposure to PCBs. There was no effect on the ages at which pubertal states in boys were attained. There was some tendency for girls with higher transplacental PCB or DDE exposure to mature earlier, but the differences were not significant. Girls with the highest transplacental PCB exposures were heavier for their heights than other girls by 5.4 kg, but differences were significant only if the analysis was restricted to white girls. In Taiwan in 1979, more than 2000 people were poisoned by heat-degraded PCBs. We have shown that, after 13 years of follow-up, the survivors have an increase in mortality from non-malignant liver disease; however, they do not yet show an excess of liver cancer, which is occurring in survivors of a similar poisoning in Japan in 1969. We continue to follow this cohort, including the children born to poisoned mothers. In Taiwan, we are beginning design of a clinical and endocrinological study of peri-pubertal girls who were in utero when their mothers were poisoned by PCBs/PCDFs