Enhancing vaccine efficacy by harnessing dendritic cell receptors and their unique properties

利用单克隆抗体作为“魔弹”，将疫苗靶向于体内的特殊细胞，可以实现有效的疫苗接种。我们表明，通过使用识别Clec9A的单克隆抗体靶向这些特殊细胞是有效的，也许是因为它将几种不同的免疫细胞聚集在一起，以便它们协调非常有效的免疫反应。该应用程序研究了靶向Clec9A如何允许强疫苗接种，以便我们可以将其应用于新一代疫苗。

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We show that targeting these special cells by using monoclonal antibodies that recognise Clec9A is effective, perhaps because it brings several different immune cells together so that they orchestrate very efficient immune responses. This application investigates how targeting Clec9A allows strong vaccination so that we can apply this to new generation vaccines.