Epidemiology, pathogenesis and prevention of group A streptococcal infection

A组链球菌(GAS)是一种具有全球意义的严格意义上的人类细菌性病原体，是十大传染病杀手之一。目前还没有商业化的疫苗。这项研究将调查气体暴发的流行病学，重点是中国正在进行的猩红热疫情。我们将试图了解GAS的发病机制以及人类宿主如何抵抗感染。我们将使用新发现的GAS抗原进行实验性疫苗试验。

Group A streptococcus (GAS) is a strictly human bacterial pathogen of global significance, that ranks among the top 10 infectious disease killers. A commercial vaccine is not available. This research will investigate the epidemiology of GAS outbreaks, focussing on the ongoing scarlet fever outbreak in China. We will seek to understand the mechanisms of GAS pathogenesis and how the human host resists infection. We will undertake experimental vaccine trials using newly discovered GAS antigens.