Multi-ethnic Study Of Atherosclerosis - Vision Component

多种族动脉粥样硬化研究（梅萨）是一项多中心、队列研究，其中对6，500名45-84岁患有亚临床心血管疾病的高加索人、西班牙人、非洲裔美国人和亚裔美国人男性和女性进行了10年随访，以确定进展为明显心血管疾病的预测因素。梅萨研究由NHLBI赞助，并根据合同提供资金。MESA-EYE部分（屈光和眼底照相）于2002年9月第第二台面访视时开始。目的是记录视网膜微血管变化的存在和严重程度（从数字视网膜照片中读取），这些变化指示黄斑变性和糖尿病视网膜病变，并描述它们与大血管疾病的横截面和纵向测量的相互关系，包括高血压，糖尿病，炎症，内皮功能障碍，以及脑结构和功能的各种标志物。视力/客观屈光部分将允许我们按性别和种族估计视力损害，确定通过更好的屈光矫正可以减少损害的程度，并将视力损害与眼底照相结果相关联。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter, cohort study in which a population-based sample of 6,500 Caucasian, Hispanic, African-American and Asian-American men and women aged 45-84 with subclinical cardiovascular disease are followed for 10 years to identify factors predictive of progression to overt cardiovascular disease. The MESA study is sponsored by NHLBI and is funded under contract. The MESA-EYE component (refraction and fundus photography) began in September 2002 at the second MESA visit. The aims are to document the presence and severity of retinal microvascular changes (as read from digital retinal photos) indicative of macular degeneration and diabetic retinopathy and to describe their interrelationships with cross-sectional and longitudinal measures of macrovascular disease, including hypertension, diabetes, inflammation, endothelial dysfunction, and various markers of brain structure and function. The visual acuity/objective refraction component will allow us to estimate visual impairment by sex and ethnicity, determine the degree to which impairment could be reduced with better refractive correction, and to correlate visual impairment with fundus photography findings.