Statistical genetic analysis of asthma-related traits

本项目旨在对弗吉尼亚州丹吉尔岛切萨皮克湾一个与世隔绝的渔村的血清总IgE水平(TIGE)进行分离分析。在一个完整的确定方案下，可以获得70%的人口的表型数据，所有个体都可以追溯到1722年，在一个单一的复杂谱系中相连。分析包括：1)TIGE的分离分析，仅使用受限的家系数据是可行的；以及2)在数量性状的分离分析中利用这种受限的家系信息的影响。分离分析的初步结果将在2002年10月举行的美国人类遗传学学会年会上公布。两份手稿正在准备提交。

This project is aimed at the segregation analysis of total serum IgE levels (tIgE) in an isolated fishing village in the Chesapeake Bay; Tangier Island, VA. Under a complete ascertainment scheme, phenotype data are available on 70% of the population with all individuals connected in a single complex pedigree dating back to 1722. Analyses include: 1) the segregation analysis of tIgE, for which use of only restricted genealogical data is feasible; and 2) the impact of utilizing this restricted genealogical information in a segregation analysis of a quantitative trait. Preliminary results of the segregation analysis will be presented at the annual American Society of Human Genetics meeting in October 2002. Two manuscripts are in preparation for submission.