Experience-dependent maturation and plasticity of the cerebral cortex mediating schizophrenia-like endophenotypes

我们将使用精神分裂症的遗传小鼠模型来了解特定的异常行为是如何引起的，重点关注大脑内的细胞和分子。我们将研究基因突变如何破坏脑细胞（神经元）之间的交流和生产，以及精神和身体活动的作用。这个项目的结果不仅对理解精神分裂症有意义，而且对其他涉及认知问题的脑部疾病也有意义，比如痴呆。

We will use genetic mouse models of schizophrenia to understand how specific abnormal behaviours are caused, focusing on cells and molecules within the brain. We will investigate how the gene mutations disrupts communication between, and production of, brain cells (neurons), and the role of mental and physical activity. The results of this project will not only have implications for understanding schizophrenia, but also for other brain disorders involving cognitive problems, such as dementia.