CCCWFU Research Base Grant

描述（由申请人提供）： 维克森林大学综合癌症中心（CCCWFU）社区临床肿瘤学计划（CCOP）研究基地于9/99（追溯至6/99）获得三年资助。本申请描述了研究基地作为控制/治疗CCOP研究基地的五年竞争性更新的管理结构，包括安全性和监测程序以及临床研究活动。研究基地的参与者包括三个CCOP（东南癌症控制联盟，温斯顿-塞勒姆，北卡罗来纳州;上州卡罗莱纳CCOP，斯帕坦堡，南卡罗来纳州;格林维尔CCOP，格林维尔南卡罗来纳州）和四个非CCOP预防成员（东卡罗莱纳大学，格林维尔，北卡罗来纳州;高点区域卫生系统，高点，北卡罗来纳州;社区间癌症中心，罗马，佐治亚州; WakeMed系统，卡里，北卡罗来纳州。这三个CCOP和四个预防成员所覆盖的地理区域包括七个州（北卡罗来纳州，南卡罗来纳州， 弗吉尼亚州，西弗吉尼亚州，肯塔基州，田纳西州，佐治亚州），人口约1200万人，其中四分之一是少数民族（60%的少数民族在沿海NC社区），由28个癌症中心提供服务。预计到2001年12月，另外3-6名CCOP和少数民族CCOP将加入CCCWFU CCOP研究基地。申请中描述了研究基地正在进行的临床试验。在癌症控制方面，有4个活跃的和13个发展中的 研究，重点是以下领域：补充和替代医学，症状管理和生活质量，特别是在癌症相关的疲劳，厌食/减肥，抑郁症，潮热，认知和化学预防的情况下。在癌症治疗方面，有6项正在进行的研究和7项正在进行的研究，主要集中在肺癌，胰腺癌和脑癌的补充，替代和常规疗法。的光谱 CCCWFU CCOP研究基地提供的临床研究是对合作组研究基地提供的癌症控制/治疗方案的补充，而不是竞争。在首席研究员Edward G.肖，医学博士，CCCWFU的临床研究管理行政结构和主要领导 来自CCCWFU、CCOPs和预防成员、CCCWFU CCOP研究基地 正在实现其主要目标，即为美国东南部的CCOP和患者（包括少数民族）提供最先进的以干预为导向的癌症预防/控制临床研究。

DESCRIPTION (provided by applicant): The Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base was funded in 9/99 (retroactive to 6/99) for three years. This application describes the administrative structure, including safety and monitoring procedures and clinical research activities of the Research Base for its five-year competitive renewal as a control/treatment CCOP Research Base. Participants in the Research Base include three CCOPs (Southeast Cancer Control Consortium, Winston-Salem, NC; Upstate Carolina CCOP, Spartanburg, SC; Greenville CCOP, Greenville SC) and four non-CCOP Prevention Members (East Carolina University, Greenville, NC; High Point Regional Health System, High Point, NC; InterCommunity Cancer Center, Rome, GA; WakeMed System, Cary, NC. The geographic region covered by these three CCOPs and four Prevention Members includes seven states (NC, SC, VA, WV, KY, TN, GA) with a population of approximately 12 million people, one-quarter of whom are minorities (60% minorities in coastal NC communities), served by 28 cancer centers. It is anticipated that an additional 3-6 CCOPs and Minority-Based CCOPs will join the CCCWFU CCOP Research Base by 12/01. Active and developing clinical trials of the Research Base are described in the application. In cancer control, there are 4 active and 13 developing studies, focusing on the following areas: complimentary and alternative medicine, symptom management, and quality of life, particularly in the setting of cancer related fatigue, anorexia/weight loss, depression, hot flashes, cognition and chemoprevention. In cancer treatment, there are 6 active and 7 developing studies, focusing on complementary, alternative, and conventional therapies primarily in lung, pancreas, and brain cancer. The spectrum of clinical research studies offered by the CCCWFU CCOP Research Base is complementary to, rather than competitive with, the cancer control/treatment protocols offered by the Cooperative Group Research Bases. Under the direction of Principal Investigator Edward G. Shaw, M.D., the Clinical Research Management administrative structure of the CCCWFU, and key leadership from the CCCWFU, CCOPs, and Prevention Members, the CCCWFU CCOP Research Base is fulfilling its primary goal of providing state-of-the-art intervention oriented clinical research studies in cancer prevention/control to CCOPs and patients (including minorities) in the Southeast United States.