NIEHS Statistical Consulting Service

统计咨询处（SCS）于1996年正式成立，为研究所研究活动的实验结果的设计、分析和解释提供统计和计算方面的专业知识。统计局提供的统计专业知识范围从数据分析方面的建议到更广泛的合作研究工作，从而在主题期刊上共同发表文章。这些咨询项目涉及各种各样的科学努力，包括实验室和人体研究。生物统计处的一些统计人员在不同程度上参与了国家统计局的工作。本资源回顾报告总结了上述生物统计处统计人员为实验室研究项目提供的咨询/合作。2004财年，超过75名科学家利用了南海。其中一些活动涉及国家毒理学计划（NTP）的长期啮齿动物致癌性研究。在2004财年，我们为编写15份国家结核控制规划技术报告和正在编写的其他7份报告提供了大量投入。

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results from Institute research activities. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by theBiostatistics Branch statisticians identified above for projects dealing with laboratory research. Over 75 scientists made use of the SCS in FY2004. Some of these activities involved the National Toxicology Program's (NTP's) long term rodent carcinogenicity studies. During FY2004 we provided significant input into the preparation of 15 NTP Technical Reports and 7 others which are in preparation. Examples of other published collaborations include (i) a study of the effect of in utero postnatal exposure Zidovudine and Larnivudine on the mitochondrial damage of mouse pup cardiomyocytes. (ii) a study of the effect of PGE2 receptors and cAMP-PKA on IL-1a induced mucin production in human airway epithelium. (iii) an evaluation of sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. (iv) an evaluation of Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis - A new model for avascular necrosis of bone. (v) a study of exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds.