ACTIVITY 5: CORE SUPPORT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。核心支持活动的主要目标是发展最先进的设施，直接支持RCMI的研究活动。第二个目标是升级夏威夷大学马诺阿分校的生物、生物医学和生物技术研究的基础设施。这三个核心设施是太平洋生物科学研究中心的分子生物学核心设施(MBCF)、计算机网络支持设施(CNSF)和医学院的生物统计和数据管理设施(BDMF)。分子和计算机设施都是已建立的单位，但需要扩展以利用这些领域的快速技术进步。生物统计设施是在RCMI的支持下于2004年建立的，目的是满足研究人员日益增长的需求，这些研究人员目前和潜在的校外研究支助需要专家生物统计咨询和服务。分子生物学核心设施的具体目标是1)提供高效率和低成本效益的DNA测序、寡核苷酸合成、基因分型、DNA微阵列分析和生物信息学服务，以及2)在新兴研究和应用技术方面发展先进的专业知识，包括结构和功能基因组学、蛋白质组学和分子遗传病理学。计算机网络支助基金的具体目标是：1)扩大网络能力，包括合作研究人员获取数据的专用研究服务器和基于网络的应用程序；2)通过硬件、软件、安全、外围设备和培训支持，管理研究人员个人的台式和膝上型计算机。生物统计和数据管理设施的具体目标是1)向临床和基础研究人员提供统计和数据管理咨询和服务，首先是那些参与RCMI计划的人，以及2)将该设施建立为UHM所有生物医学研究人员可用的持续核心资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of the Core Support activity is the development of state-of-the-art facilities to directly support the RCMI research activities. The secondary goal is to upgrade the infrastructure for biological, biomedical and biotechnological research at the University of Hawaii at Manoa. The three core facilities are the Molecular Biology Core Facility (MBCF), the Computer Network Support Facility (CNSF), both in the Pacific Biosciences Research Center and the Biostatistics and Data Management Facility (BDMF) in the School of Medicine. Both the molecular and computer facilities were established units, but were in need of expansion to exploit the rapid technological advances in these fields. The biostatistics facility was created in 2004 with RCMI support to meet the growing needs of researchers whose current and potential extramural research support requires expert biostatistical consultation and services. The specific aims of the Molecular Biology Core Facility are 1) to provide efficient and cost-effective DNA sequencing, oligonucleotide synthesis, genotyping, DNA microarray analysis and bioinformatics services, and 2) to develop progressive expertise in emerging research and applied technologies, including structural and functional genomics and proteomics and molecular genetic pathology. The specific aims of the Computer Network Support Facility are 1) to expand network capability to include dedicated research servers and web-based applications for data access by collaborating researchers, and 2) to manage the desktop and laptop computers of individual researchers with hardware, software, security, peripherals and training support. The specific aims of the Biostatistics and Data Management Facility are 1) to provide statistical and data management consultation and services to clinical and basic researchers, initially to those with the RCMI program, and 2) to establish the facility as an ongoing core resource available to all biomedical researchers at UHM.