BABOON IMMUNE RESPONSES TO NP-ISS + INFLUENZA VACCINE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本实验的目的是确定NP-1018和NP-C295与商业流感疫苗的混合是否改善狒狒对由血凝素抗原（HA）组成的流感疫苗的免疫应答。本项狒狒研究将检测两种新制剂（NP-1018和NP-C295），其由与流感病毒重组核蛋白（NP）结合的免疫刺激DNA序列（ISS）组成。 本研究将包括6组，每组5只动物

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this experiment is determine if mixing NP-1018 and NP-C295 with commercial influenza vaccine improves the immune responses of baboons to influenza vaccine, consisting of hemaglutinnin antigen (HA). This study in baboons will test two new formulations (NP-1018 and NP-C295) consisting of immunostimulatory DNA sequences (ISS) conjugated to recombinant nuclear protein (NP) of influenza virus. This study will consist of 6 groups of 5 animals per group