EVALUATION OF SIV EXPRESSING IGIF

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。白细胞介素-18（IL-18，干扰素-γ诱导因子[IGIF]）代表先天性（吞噬细胞和NK细胞）和适应性（T淋巴细胞和B淋巴细胞）免疫系统的效应细胞之间的功能联系。通过减毒活SIV疫苗表达IL-18可降低病毒毒力并诱导可预防致病性SIV感染的I型免疫应答。本研究的目的是评估重组SIV感染恒河猴的体内效应？表达恒河猴IL 18基因的nef及其作为减毒活疫苗（SIVIL 18）的潜在用途。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Interleukin-18 (IL-18, interferon-gamma inducing factor [IGIF]) represents a functional link between effector cells of the innate (phagocytic and NK cells) and adaptive (T- and B-lymphocytes) immune systems. Expression of IL-18 by a live-attenuated SIV vaccine may reduce viral virulence and induce a Type-1 immune response that may prevent infection with pathogenic SIV. The objective of this study was to evaluate the in vivo effects of the infection of rhesus macaques with a recombinant SIV?nef that expresses the rhesus IL18 gene and its potential use as a live-attenuated vaccine (SIVIL18).