USE OF CLONIDINE TO REDUCE DIARRHEA LOSSES IN PATIENTS WITH PROXIMAL JEJUNOSTOMY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。小肠切除术后的患者需要静脉营养，以满足日常的营养和液体需求。然而，尽管有常规治疗、饮食控制和静脉输液，一些肠道剩余量非常有限的患者发生严重脱水的风险尤其增加。此外，粪便损失越大，电解质和微量元素的损失也越大。这项初步研究将测试高血压药物可乐定，以确定它是否有助于减少这类患者的腹泻和电解质流失。患者将在GCRC的基线期进行研究，随后是治疗期。他们将充当自己的控制者。治疗将包括0.5毫克可乐定贴片应用一个星期。将在基线和治疗后完成全面的营养平衡测试。可乐定已被证明可用于治疗与腹泻相关的腹泻损失和与霍乱相关的电解质损失。这种药物也显示出对小肠的抗蠕动作用，因此，可能会增加运输时间，允许更有效的肠道营养和电解质吸收。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients who have had massive resection of their small intestine require intravenous nutrition in order to supply their daily nutritional and fluid requirements. However, some patients with very limited remaining intestine are at especially increased risks for severe dehydration despite conventional therapies, dietary manipulation, and intravenous fluids. In addition, the greater the fecal losses, the greater the electrolyte and trace element losses. This pilot study will test the hypertenive medication clonidine to determine if it may be useful in decreasing diarrheal and electrolyte loses in such patients. Patients will be studied during a baseline period in the GCRC followed by a treatment period. They will act as their own controls. Treatment will consist of a 0.5 mg clonidine patch applied for a week. A comprehensive battery of nutrient balance tests will be completed at baseline and following treatment. Clonidine has proven useful for the treatment of diarrheal losses associated with diarrhea and electrolyte losses associated with cholera. This medication has also been shown to exhibit anti motility effects on small intestine, and therefore, may increase transit time, allowing for more efficient intestinal nutrient and electrolyte absorption.