EFFECT OF CLA SUPPLEMENTS ON BODY WEIGHT AND FAT OXIDATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究结束了。自1970年以来，美国肥胖成年人的数量大幅增加。目前，美国超过60%的成年人超重或肥胖。然而，通过饮食和运动来减轻体重来治疗肥胖症只是适度有效，因为大多数人往往会在治疗后五年内恢复他们可能失去的体重。因此，我们调查了一种安全的膳食补充剂的效果，这种补充剂已知可以减少动物的肥胖。我们在受试者身上进行了一项为期六个月的对照临床试验，以确定共轭亚油酸(CLA)在减脂和脂肪燃烧方面的疗效。一半的受试者每天服用CLA和一半的非活性油，而研究人员和参与者都不知道他们是服用了CLA还是非活性油。49名健康、超重的成年人接受了研究。他们接受了健康生活方式的建议，包括轻度到中度的体力活动，减少膳食脂肪和增加膳食纤维摄入量。超重成年人服用6个月的CLA补充剂后，体内脂肪减少了3.7磅，而食用非活性油的受试者在假日期间增加了2磅。这表明，共轭亚油酸可能在减少成年期间的累积体重和脂肪增加方面发挥作用，特别是在许多人体重增加的假日季节。与非活性油相比，共轭亚油酸治疗增加了睡眠期间的脂肪燃烧。这一增加表明，共轭亚油酸通过增加一个人燃烧的脂肪量来起作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is closed. There has been a large increase in the number of obese adults in the United States since 1970. Currently, over 60% of adults in the U.S. are overweight or obese. Treatment of obesity by diet and exercise to reduce body weight, however, has only been moderately effective as most individuals tend to regain any weight they may have lost within five years after treatment. We therefore investigated the effects of a safe dietary supplement that is known to reduce obesity in animals. We performed a controlled six-month clinical trial in human subjects to determine the efficacy of conjugated linoleic acid (CLA) in fat loss and fat burned. Half of the subjects received daily supplements of CLA and half an inactive oil in a way in which neither the people running the study nor the participants know if they are receiving CLA or the inactive oil. Forty-nine healthy, overweight adults were studied. They were counseled on a healthy lifestyle including mild to moderate physical activity, decreased dietary fat and increased dietary fiber consumption. Six months of CLA supplementation among overweight adults reduced body fat by 3.7 lbs while the subjects eating the inactive oil gained 2 lbs during the holiday season. This indicates that CLA may play a role in lessening the cumulative weight and fat gains that occur during adulthood, particularly during the holiday season when many people gain weight. The CLA treatment increased fat burning during sleep compared to the inactive oil. The increase indicates that CLA acts by increasing how much fat a person burns.