A 12 WEEK DOUBLE BLIND PLACEBO CONTROLLED STUDY OF GINKO BILOBA AUGMENTATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。研究标准化银杏叶提取物(GB)在治疗精神分裂症症状，特别是阴性症状和/或改善他们的大脑功能和记忆方面是否可能是有用的附加剂。这项研究将采用双盲、随机、安慰剂对照设计，将包括100名难治性精神分裂症患者。受试者将被随机接受标准剂量的GB或安慰剂治疗12周，此外，在进入研究之前，他们还将继续接受被认为是最佳的抗精神病药物治疗。标准评估工具将用于衡量症状(包括阳性和阴性)、神经认知表现和功能状态的变化。评估将在基线以及第2、4、6和12周结束时进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To examine whether standardized estracts of Ginko biloba (Gb) might be a useful added agent in treating symptoms of schizophrenia, particularly negative symptoms and/or improve their brain function and memory. The study will use a double-blind, randomized, placebo-controlled design, and will include 100 subjects with treatment resistant schizophrenia. Subjects will be randomized to receive either a standard dose of Gb or placebo for 12 weeks in addition to continuing their treatment with anti psychotic medications that have been judged as optimal prior to entering the study. Standard assessment instruments will be used for measuring changes in symptoms (both positive and negative), neurocognitive performance and functioning status. Assessments will be done at baseline, and at the end of weeks 2,4,6 and 12.