SEARCH FOR DIABETES IN YOUTH OF THE PUGET SOUND

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。有关美国青年糖尿病患病率和发病率的数据有限，各种糖尿病类型的比例尚不清楚。临床因素和胰岛素需求不再可靠地区分儿童糖尿病的类型。在青少年中搜索糖尿病是一种全国性的、多中心的、统一的方法，用于儿童和青少年糖尿病的病例确定、类型学、监测和研究，它将根据糖尿病的类型、年龄、性别和种族/民族来衡量美国20岁以下青年人口中糖尿病的程度。次要目标包括开发实用的方法来确定糖尿病类型，按类型描述儿童糖尿病及其并发症，并描述卫生保健利用、护理过程和生活质量。全国六个中心的研究人员正在对600万具有广泛种族和社会经济代表性的青年(约占20名UW人口的6%)进行监测，2001年确认了大约6000例糖尿病流行病例，2002-2004年每年发现800例糖尿病病例。华盛顿研究的人群是2001-2004年间所有20岁以下居住在普吉特湾的糖尿病青年，包括大约1500个流行病例和600个事件病例。Search正在通过有限的数据、调查、简短的体检(身高、体重、血压、腰围到臀部的测量和对黑棘皮病的评估)、实验室研究(糖尿病自身抗体、禁食和刺激的C-肽、血红蛋白A1c、血糖、血脂、尿白蛋白、肌酐、DNA提取和血浆储存)和面谈调查(诊断日期和背景；诊断时的临床表现、年龄和体型；其他病史和处方药的使用；种族/民族和社会经济状况、家庭结构和生活质量)收集信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data on prevalence and incidence of diabetes in US youth is limited and proportions with various diabetes types are unknown. Clinical factors and insulin requirements no longer reliably differentiate types of childhood diabetes. SEARCH for Diabetes in Youth is a national, multi-center, uniform approach to case ascertainment, typology, surveillance and research on diabetes in children and adolescents that will measure the extend of diabetes in the US population of youth under the age of twenty by type of diabetes, age, gender and race / ethnicity. Secondary objectives include developing practical approaches to identifying diabetes type, describing childhood diabetes and its complications by type, and characterizing health care utilization, processes of care and quality of life. Researchers at six centers across the country are conducing surveillance on 6 million youth with wide ethnic and socioeconomic representation (~6% of the 20 UW population), identifying approximately 6000 prevalent diabetes cases in 2001, and 800 incident cases per year in 2002-2004. The Washington study population is all youth with diabetes in 2001-2004 who are under age 20 and reside in the Puget Sound, which includes approximately 1500 prevalent and 600 incident cases. SEARCH is collecting information through limited data, surveys, brief physical examinations (height, weight, blood pressure, waist to hip measurement and assessment for acanthosis nigricans), laboratory studies (diabetes autoantibodies, fasting and stimulated C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine, DNA extraction, and plasma storage), and interview surveys (date and setting of diagnosis; clinical presentation, age and body size at diagnosis; other medical history and use of prescription medications; race / ethnicity and socioeconomic status, family structure, and quality of life).