ALZHEIMERS DISEASE DATA COORDINATING CENTER

与这些陈述的主要目标相关联的目标是“重要和新颖的研究问题可以得到解决，这在任何一个中心的可用资源都是不可能的”，并且这些研究活动，使用数据协调中心的资源，“可以通过通常的NIH和其他联邦和非联邦来源来资助研究者发起的申请”。我们已将既定目标重组为我们提议的阿尔茨海默病数据协调中心的具体目标：1。迁移，继续数据流，并维护现有的最小数据集（MDS），提供访问中心，安全和数据质量控制的手段；2. 利用MDS数据建立辅助数据库，对参与adc的组织和生物标本进行编目；描述现有标本的数量和类型，并在确保数据安全和保密的同时便利调查人员之间的联系；3. 就最适合MDS和生物标本数据库的研究问题、研究设计和分析方法提供统计和流行病学咨询；4. 促进adc之间的合作研究，以解决“扩展”数据收集最能解决的研究问题：确保可行性研究的严格设计/分析标准；通过发展协调会与指导委员会共同提供可行性研究的审查和资助机制，要求采用假设驱动的方法来“扩大”、回顾性和前瞻性数据收集；根据督导委员会与艺发局主任的决定，就重要或新颖的研究课题进行设计和分析；5. 参与将成功的可行性研究扩展到由其他方式资助的全adc（或联合体）倡议；就这些研究的设计和分析提供咨询意见，以便在需要和可行的情况下为这些研究提供“核心”统计和数据库功能。

The goal associated with these stated primary objectives is that "important and novel research issues can be addressed which would not be possible with the resources available at any one center" and that these research activities, using the resources of the data coordination center, "may be supported through the usual NIH and other federal and non-federal sources for funding investigator initiated applications". We have re-structured the stated objectives into Specific Aims for our proposed Alzheimer's Disease Data Coordinating Center: 1. To migrate, continue data flow, and maintain the existing Minimum Data Set (MDS) providing means of access to the centers, security and data quality control; 2. To use the MDS data to establish an auxiliary database which catalogs tissues and biological specimens available at participating ADCs; to describe numbers and types of specimens available and facilitate contact between investigators while maintaining data security and confidentiality; 3. To provide statistical and epidemiologic consulting concerning research questions, study designs, and analytic methods best suited to the MDS and the biologic specimen database; 4. To foster collaborative research among ADCs for research questions best addressed by "expanded" data collection: to insure rigorous design/analysis standards for feasibility studies; to provide a mechanism for review and funding of Feasibility studies through the ADDCC in conjunction with the Steering Committee to require a hypothesis-driven approach to "expanded", retrospective and prospective data collection; to formulate designs and analyses for important or novel research questions, as determined by the Steering Committee in conjunction with the ADC directors; 5. To participate in the expansion of successful feasibility studies toward ADC-wide (or consortium) initiatives which would be funded by other means; to provide consultation on the design and analysis of those studies to provide, as needed and as feasible, the 'core' statistical and database functions for those studies.