Research Training in Hematology

描述（由申请人提供）：目前的培训计划汇集了来自校园九个部门的20名教员，重点关注血液和人类疾病的两个广泛重要领域：血管生物学和干细胞生物学/血液恶性肿瘤。这项资助的主要目标是培养具有杰出潜力的医学博士和博士科学家，在这些领域开展持续的、独立的研究项目。为了充分利用威斯康星大学优秀的医学博士候选人和强大的研究生课程的悠久传统，我们要求两个博士前职位。4个博士后职位将从参与项目的临床科室（内科、儿科、病理学和外科）的临床研究员或住院医师，以及参与项目的基础科学科室（解剖学、生物化学、生物统计学、微生物学和药理学）的博士生中选择。教师是一个稳定和互动的小组，集中在三个主要的兴趣组：止血/炎症的基础和临床方面，血液恶性肿瘤和人类干细胞/骨髓移植。我们的教师在基础科学和临床科学方面都有广泛的专业知识，包括基因阵列和基因组学的实验方法、转录和转录后基因表达、蛋白质结构分析、蛋白质组学、细胞生物学、造血和内皮细胞培养、小鼠动物模型、灵长类动物和人类胚胎干细胞以及骨髓移植。重点是提供追求转化研究机会所需的多学科培训，以及临床研究者的正式培训。我们的培训项目利用威斯康星大学的临床研究者预备项目（K30资助），为从事转化研究项目的候选人提供临床试验设计和生物统计学方面的教学培训。该项目在留住学院派医学学员方面有着良好的记录。在我们的8名博士预科候选人中，有6人继续攻读博士学位，2人已经完成学位并在外部机构（哈佛大学，梅奥大学）获得了优秀的博士后职位。我们的11名博士后候选人现已完成他们的研究训练。其中6人是成功的学术研究人员，2人是生物技术公司的活跃研究人员（包括一名研究主任），1人在医学院。我们已经成功地招募了四个代表性不足的少数族裔，其中一半的被任命者是妇女。大量合格的候选人，我们的培训师出色的指导能力，优秀的核心设施，机构承诺，以及广泛的科学专业知识，促进了多学科方法，这将确保我们的学员在科学领域取得成功。

Description (provided by applicant): The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.