Research Training in Bioenergetics, Oxidative Stress & Metabolic Syndromes

描述(由申请人提供)： 我们提出了一个培训计划，旨在吸引和培训博士后和博士后科学家研究生物能量学和氧化应激在代谢综合征病理生理学中的作用。该培训计划的目标是在基础研究和临床研究领域培养有才华的年轻人，教他们设计和执行成功的研究项目，并为他们提供坚实的科学研究伦理和方法背景。该奖学金的目标是增加MUSC对代谢综合征、生物能量学和氧化应激的研究重点，并培养个人成为对代谢综合征和相关疾病领域感兴趣的独立研究人员和学术人员。受训人员将从众多候选人中挑选出来。将特别努力识别少数族裔申请者。该培训计划旨在分别为博士后和博士后研究员提供为期两年和三年的全职工作经验，与一群有才华的教师导师一起工作。研究项目集中在生物能量学和氧化应激领域，因为它们与代谢综合征的各个方面有关，包括胰岛素抵抗、糖尿病、肥胖、血脂异常、肝脏脂肪变性、炎症以及随之而来的组织损伤，特别是对肝脏和肾脏的损伤。每周与受训者举行会议，使他们能够向研究界介绍他们的材料。此外，受训者被要求在内部部门研讨会上介绍他们的研究，并向全国会议提交摘要。博士前学生将通过研究生院入学，并遵循生物医学博士的学习课程。在接受了细胞、分子和生物生物学的基本培训后，博士后学员将与博士后学员一起参加一个名为《代谢综合征中的生物能量学和氧化应激(S)》的研究生课程。所有受训人员将参加临床研究方法、负责任的研究方法和统计学方面的必修课程。学员还将在南加州大学就众多研究课题提供研究生级别的课程，以增强他们的培训经验。 公共卫生相关性：我们的计划侧重于与代谢综合征相关的生物能量学和氧化应激方面的研究培训，代谢综合征是一系列临床疾病，最显著的是肥胖、胰岛素抵抗、2型糖尿病、血脂异常、高血压和非酒精性脂肪性肝病。代谢综合征在美国约有5000万人，易诱发动脉粥样硬化、冠心病、中风等疾病，因此代谢综合征及其表现的治疗是降低这些疾病发病率和死亡率的关键。

DESCRIPTION (provided by applicant): We propose a training program designed to attract and train pre- and post-doctoral scientists in research on the roles of bioenergetics and oxidative stress in the pathophysiology of metabolic syndrome. The goals of this training program are to nurture talented young individuals in the areas of basic research and clinical investigation, to teach them to design and perform successful research projects, and to give them a solid background in the ethics and methods of scientific research. The objective of this fellowship is to increase the focus of research on metabolic syndrome, bioenergetics, and oxidative stress within MUSC and to train individuals to become independent investigators and academic faculty with an interest in the area of metabolic syndrome and related diseases. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants. The training program is designed to provide experience for two and three years, respectively, of full-time effort for postdoctoral and predoctoral fellows working with a group of talented faculty mentors. Research projects are concentrated in the areas of bioenergetics and oxidative stress as they relate to the various aspects of the metabolic syndrome, including insulin resistance, diabetes, obesity, dyslipidemia, hepatic steatosis, inflammation, and consequent tissue injury, especially to the liver and kidney. Weekly conferences with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at in-house departmental seminars and submit abstracts to national meetings. Predoctoral students will matriculate through the College of Graduate Studies and follow the course of study for the PhD in Biomedical Sciences. After receiving basic training in cell, molecular, and organismal biology, predoctoral trainees will participate in a graduate course on "Bioenergetics and Oxidative Stress in the Metabolic Syndrome(s)"together with postdoctoral trainees. All trainees will attend required courses in methods in clinical research, responsible conduct of research, and statistics. Trainees will also be offered graduate-level courses on numerous research topics at MUSC to enhance their training experience. PUBLIC HEALTH RELEVANCE: Our program focuses on research training in bioenergetics and oxidative stress related to metabolic syndrome, which is a constellation of clinical conditions, most notably obesity, insulin resistance, Type-2 diabetes, dyslipemia, hypertension, and nonalcoholic fatty liver disease. Affecting about 50 million in the US, metabolic syndrome predisposes atherosclerosis, coronary heart disease, stroke and other diseases, so treatment of metabolic syndrome and its manifestations is key to decreasing morbidity and mortality from these diseases.